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| Product Name | Mouse IL-15/IL-15R ELISA |
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| Description | IL-15 is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, beta and gamma, are shared with the IL-2 receptor, while the alpha subunit is unique to IL-15. Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15Ralpha. This chaperoning is required from the ER to Golgi through to secretion. The cytokine/receptor complex may stay bound to the cell surface, where it can be trans- presented to cells expressing the beta-gamma subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages, and demonstrates a 10- 100-fold increase in agonistic activity over IL-15 alone. Sample Types: cell culture, EDTA plasma, serum. Sample Size: 50 µL. Range: 6.3 - 400 pg/mL. Sensitivity: 2.0 pg/mL. Time: 3hr 30min |
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| Size | 96 wells |
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| Concentration | n/a |
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| Applications | Immunoassays. Research Use Only. Not for Use in Diagnostic Procedures. |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 61-I15MS-E01 |
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| Order / More Info | Mouse IL-15/IL-15R ELISA from ALPCO |
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| Product Specific References | n/a |
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