| 产品详情 |
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| Product Name | GW 856553X |
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| Description | Purity >98%. GW 856553X is a selective inhibitor of p38Alpha and p38Beta MAPK (pKi = 8.1 and 7.6, respectively in isolated enzyme assays). It inhibits TNF-Alpha production (IC50 = 31 nM) in human peripheral blood mononuclear cells. It improves survival and normalizes blood pressure in rats with hypertension induced by a high salt and fat diet. It also has positive effects on cardiac remodeling and reduces HDL, LDL, and triglycerides in rats. In a clinical trial of patients with acute myocardial infarction, GW 856553X did not reduce the risk of major ischemic cardiovascular events. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide, GSK-AHAB, SB 856553 |
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| Gene, Accession, CAS # | CAS: 585543-15-3 |
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| Catalog # | LS-H8057 |
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| Order / More Info | GW 856553X from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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