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| Product Name | HNRNPK, Recombinant, Human, aa3-459, GST-Tag (Heterogeneous Nuclear Ribonucleoprotein K) |
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| Description | Purity ~90% (SDS-PAGE). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. Source: Recombinant protein corresponding to aa3-459 from human HNRNPK, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~77.2kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Transformation up-regulated nuclear protein, TUNP |
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| Gene, Accession, CAS # | SwissProt: P61978 |
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| Catalog # | 373670 |
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| Order / More Info | HNRNPK, Recombinant, Human, aa3-459, GST-Tag (Heterogeneous Nuclear Ribonucleoprotein K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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