| 产品详情 |
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| Product Name | Eeyarestatin 1 |
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| Description | Purity >98%. Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3. Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl] hydroxyamino]-5,5-dimethyl-2-oxo-1- imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide |
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| Gene, Accession, CAS # | CAS: 412960-54-4 |
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| Catalog # | LS-H7621 |
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| Price | |
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| Order / More Info | Eeyarestatin 1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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