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| Antigenic Specificity | MBP / Myelin Basic Protein, aa82-91 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | bovine |
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| Isotype | IgG2a |
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| Format | ascites |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, IHC, IHC-Fr (1:100), WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MBP / Myelin Basic Protein Antibody (aa82-91) LS-C25711. Specificity: It appears to react with synthetic peptide 82-91 and human and bovine 45-91 but not with whole MBP molecules (Martensen numbering). This epitope is located in the C terminal region of 82-91 and the corresponding epitope is not present (or exposed) in whole MBP. The clone was selected using synthetic human MBP peptide 82-91 for screening. Since this work was done a sequence error has been described in the human MBP sequence in this region. Although the clone was selected to have a high affinity for 82-91 it appears that this antibody reacts more strongly with the unnatural sequence, rather than the correct human 82-91. In consequence the antibody is not a suitable reagent for sensitive immunoassays of correct human 82-91 as was thought at the time the original paper on this antibody was published. The 91-92 phe-phe bond is believed to be cleaved by demyelinating lesions by Cathepsin D to generate peptides ending in the phe 91 which should react with this monoclonal. |
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| Immunogen | Bovine Myelin Basic protein (MBP) (45-91) / Ovalbumin Conjugate. |
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| Other Names | MBP, Myelin A1 protein, Myelin basic protein |
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| Gene, Accession # | MBP, Gene ID: 4155 |
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| Catalog # | LS-C25711 |
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| Price | |
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| Order / More Info | MBP / Myelin Basic Protein, aa82-91 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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