| 产品详情 |
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| Product Name | RITA |
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| Description | Purity >98%. HDM-2 (human double minute-2; MDM-2 in mouse) is a key negative regulator of p53 that binds to and targets p53 for proteasomal degradation. Overexpression of HDM-2 in some tumors leads to inactivation of p53 thereby allowing tumor cells to escape p53-induced apoptosis. RITA (reactivation of p53 and induction of tumor cell apoptosis) is a small molecule inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53. It binds to p53 with an apparent Kd of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation and activation. RITA potently inhibits the growth of a variety of cancer cell lines in the sub-micromolar range, inducing both DNA-protein and DNA-DNA cross links in human renal cancer cells. RITA reduced tumor size by 90% at a dose of 10 mg/kg in SCID mice bearing HCT116 tumors, and caused complete regression of A-498 tumor cell xenografts in nude mice at a dose of 45 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5,5'-(2,5-furandiyl)bis -2-thiophenemethanol, NSC 652287, 2,5-bis(5-hydroxymethyl-2-thienyl) Furan |
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| Gene, Accession, CAS # | CAS: 213261-59-7 |
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| Catalog # | LS-H9732 |
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| Order / More Info | RITA from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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