| 产品详情 |
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| Product Name | TAT-CBD3 |
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| Description | Purity >97% by HPLC. TAT-CBD3 is a peptide of CRMP-2 fused to the HIV transactivator of transcription (TAT) protein. It shows decreased neuropeptide release from sensory neurons and excitatory synaptic transmission in dorsal horn neurons, reduced meningeal blood flow, reduced nocifensive behavior induced by formalin injection or corneal capsaicin application and reversed neuropathic hypersensitivity produced by an antiretroviral drug. TAT-CBD3 is mildly anxiolytic without affecting memory retrieval, sensorimotor function or depression. At doses tenfold higher than that required to reduce hypersensitivity in vivo, TAT-CBD3 causes a transient episode of tail kinking and body contortion. By preventing CRMP-2-mediated enhancement of CaV2.2 function, TAT-CBD3 alleviates inflammatory and neuropathic hypersensitivity, an approach that may prove useful in managing chronic pain. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H11652 |
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| Order / More Info | TAT-CBD3 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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