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| Product Name | Calbindin, Recombinant, Rat (D28K, Vitamin D-dependent Calcium-binding Protein) |
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| Description | Purity ≥ 90% as determined by reducing and non-reducing SDS-PAGE Coomassie. Calbindins are Ca-binding proteins belonging to the troponin C superfamily. CALB28K/Calbindin1/CALB1 (D28K/Spot35 protein or cholecalcin, rat 261 aa; mouse 261 aa; human 261-aa, chromosome 8q21.3-q22.1) was originally described as 27kD induced by vitamin D in the duodenum of chicken. In mammals, it is expressed in the kidney, pancreatic islets, and brain. In brain, its synthesis is independent of vitamin D. CABP28K contains 4 active and 2 inactive EF-hand Ca-binding domains. The gene for CABP28K is clustered in the same region as carbonic anhydrase. The neurons in the brains of patients with Huntington disease are CAB28K depleted. There are two types of CaBPs: the trigger- and the buffer-CaBPs. The conformation of trigger type CaBPs changes upon Ca2+ binding and exposes regions on protein that interact with target molecules, thus altering their activity. The buffer-type CABP are thought to control the int |
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| Size | 1ug, 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C0113-17 |
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| Order / More Info | Calbindin, Recombinant, Rat (D28K, Vitamin D-dependent Calcium-binding Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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