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| Product Name | NEK2, Active, Recombinant, Human (NIMA-Related Kinase 2, Never in Mitosis A) |
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| Description | Purity ~90% (SDS-PAGE). Nek 2 is closely related in its catalytic domain to the serine/threonine protein kinase NIMA of Aspergillus nidulans that is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulated progressively throughout S, reaching maximal levels in late G2 (1). These observations demonstrate that Nek2 resembles Aspergillus NIMA, not only in its catalytic domain, but also in its cell cycle-dependent expression. Recombinant Nek2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human Nek2 and fungal NIMA phosphorylate a similar, albeit not identical, set of proteins and synthetic peptides, and beta-casein is a suitable substrate for assaying Nek2 in vitro (2). Nek2 is shown to be expressed most abundantly in the testis of the adult tissues examined (3). Its expression in the testis is restricted to the germ |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | nek 2, nek-2, Active NEK2, NEK2, human NEK2, active kinase, active kinases, NEK, recombinant NEK2, recombinant NEK, kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | NEK2, Gene ID: 4751, SwissProt: P51955 |
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| Catalog # | 220090 |
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| Order / More Info | NEK2, Active, Recombinant, Human (NIMA-Related Kinase 2, Never in Mitosis A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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