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| Product Name | Recombinant Human Cyclin-dependent kinase inhibitor 1 |
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| Description | 2-164aa; Full Length. MW: 45.5kD. Purity >90% as determined by SDS-PAGE. May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.05 mg (Yeast) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6p21] |
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| Gene, Accession, CAS # | CDKN1A, Gene ID: 1026, Accession: NP_000380.1 |
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| Catalog # | MBS961459 |
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| Order / More Info | Recombinant Human Cyclin-dependent kinase inhibitor 1 from MYBIOSOURCE INC. |
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| Product Specific References | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J.Cell 75:805-816(1993) |
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