| 产品详情 |
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| Antigenic Specificity | SYK, aa5-360 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat, human |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC, IHC-P (10 µg/ml), IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SYK Antibody (aa5-360) IHC-plus™ LS-B11825. Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation. |
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| Immunogen | Recombinant fragment corresponding to amino acids 5 - 360 of human Syk. |
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| Other Names | SYK, p72syk, Spleen tyrosine kinase, Syk protein-tyrosine kinase, Tyrosine-protein kinase SYK, p72-Syk |
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| Gene, Accession # | SYK, Gene ID: 6850 |
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| Catalog # | LS-B11825 |
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| Price | |
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| Order / More Info | SYK, aa5-360 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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