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| Product Name | GDNF, Recombinant, Human |
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| Description | Purity ~98% (RP-HPLC and SDS-PAGE). GDNF promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Source: Recombinant corresponding to human GDNF, expressed in E. coli. Molecular Weight: ~30.36kD Biological Activity: hGDNF is fully biologically active when compared to a standard. The ED50, calculated by the dose-de |
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| Size | 2ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GDNF, Recombinant, Human (Glial Cell Line-derived Neurotrophic Factor, hGDNF, Astrocyte-derived Trophic Factor, ATF) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 136898 |
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| Order / More Info | GDNF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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