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| Product Name | GDNF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). GDNF is a disulfide-linked, homodimeric neurotrophic factor that belongs to the cystine-knot family of growth factors. Natively glycosylated, GDNF signals through a multi-component receptor system that comprises of a RET and one of the four GFRalpha receptors. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Recombinant Human GDNF is a non-glycosylated, disulfide-linked homodimer (30kD) consisting of 135aa in each subunit. Source: Recombinant protein corresponding to human GDNF expressed in E. coli. Molecular Weight: ~15kD Biological Activity: The ED50 as determined by the proliferation of rat C6 cells was found to be <0.1ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GDNF, Recombinant, Human (Glial Cell Line-Derived Neurotrophic Factor, Astrocyte-Derived Trophic Factor, ATF, Glial-Derived Neurotrophic Factor) |
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| Gene, Accession, CAS # | SwissProt: P39905 |
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| Catalog # | 500035 |
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| Order / More Info | GDNF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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