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| Product Name | Insulin-like 3, Recombinant, Human (INSL3, Leydig Cell Insulin-like, Ley I-L) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin ≤ 1EU. Human INSL3 (insulin-like 3), formerly called Ley I-L (Leydig cell insulin-like), is a member of the insulin/relaxin superfamily.1-3 INSL3 is a secreted protein produced in high amounts by testicular Leydig cells, and in lower amounts by ovarian follicular theca interna cells.3, 4 As with other insulin/relaxin superfamily members, human INSL3 is synthesized as a preprohormone.1 The PreproINSL3 precursor is 131 amino acids (aa) in length. It is processed by a prohormone convertase to remove a 20 aa signal sequence and a 47 aa internal pro-, or C-peptide that separates a 35 aa N-terminal B chain from a 26 aa C-terminal A chain. The resulting mature protein is an unglycosylated 6kD complex of disulfide-linked A and B chains.1-3 The proteolytic processing site(s) for some species is uncertain. Based on human, mature human INSL3 shares 70%, 62%, 67% and 62% aa identity with canine, rat, porcine and mous |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P51460 |
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| Catalog # | I7660-85 |
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| Order / More Info | Insulin-like 3, Recombinant, Human (INSL3, Leydig Cell Insulin-like, Ley I-L) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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