| 产品详情 |
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| Product Name | PX 12 |
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| Description | Purity >97%. PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA. Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1 alpha protein levels (IC50 = 7.2 µM), as well as expression of VEGF (IC50 = 10.4 µM) and iNOS (IC50 = 18.1 µM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 µM) and HT-29 cells (IC50 = 2.9 µM) as well as reduced microvessel density in MCF-7 tumor xenografts. PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 µM) and Trx-1-increased expression and translation of CYP1B1. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(1-methylpropyl)dithio]-1H-imidazole |
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| Gene, Accession, CAS # | CAS: 141400-58-0 |
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| Catalog # | LS-H94 |
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| Price | |
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| Order / More Info | PX 12 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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