| 产品详情 |
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| Product Name | PX 866 |
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| Description | Purity >98%. PX 866 is a ring-opened analog of wortmannin that potently and irreversibly inhibits PI3K (IC50 = 0.1-88 nM). It less potently blocks the activity of mammalian target of rapamycin (mTOR, IC50 = 3.1 µM). PX 866 exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment. In cancer cells grown in three-dimensional cultures, PX 866 reduces cell growth and motility without causing cytotoxicity. Consistent with having cytostatic effects, PX 866 dosing is associated with prolonged stable disease in cancer patients. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1E,4S,4aR,5R,6aS,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione |
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| Gene, Accession, CAS # | CAS: 502632-66-8 |
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| Catalog # | LS-H9593 |
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| Price | |
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| Order / More Info | PX 866 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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