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| Product Name | Neurexin 2 alpha, Isoform 2, Recombinant, Human, Fc Chimera |
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| Description | Purity ~95% (SDS-PAGE). Neurexin 2, also known as NRXN2, is a neuronal type I transmembrane molecule that is encoded by one of three Neurexin genes (1, 2). Mature human Neurexin 2a is an ~200kD N- and O-glycosylated protein with a 1608aa extracellular domain (ECD) and a 55 aa cytoplasmic domain. The ECD contains six LNS domains interspersed with three EGF-like domains and a juxtamembrane O-glycosylation region (1-3). The ECD of human Neurexin 2a shares 98% and 99% aa sequence identity with mouse and rat Neurexin 2a, respectively. Transcription of the Neurexin 2 gene from an internal promoter gives rise to Neurexin 2B which lacks the first five LNS domains and all of the EGF-like domains (3, 4). Human Neurexin 2a is combinatorially spliced at five canonical sites in the ECD, giving rise to nearly 200 potential isoforms (4). This recombinant protein (isoform 2 according to SwissProt # Q9P2S2) does not contain inserts at splice sites 1, 2, 3,or 4. Neurexin 2a is primarily expressed in the |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Neurexin 2 alpha, Isoform 2, Recombinant, Human, Fc Chimera (Neurexin-2-alpha, Neurexin II-alpha, NRXN2, KIAA0921) |
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| Gene, Accession, CAS # | Accession: NP_620060 |
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| Catalog # | N2110-06 |
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| Order / More Info | Neurexin 2 alpha, Isoform 2, Recombinant, Human, Fc Chimera from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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