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| Product Name | TL-1A, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 15, TNFSF15, VEGI) |
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| Description | Purity ~98% (SDS-PAGE). TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Source: Recombinant protein corresponding to 194aa residues from human TL-1A, expressed in E. coli. Molecular Weight: ~22kD Biological Activity: Determined by its ability to stimulate IFN-gamma production by human PBMC using a concentration range of 10-100ng/ml. Note: Results may vary with PBMC donors. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPT |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNFSF15, VEGI |
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| Gene, Accession, CAS # | TNFSF15, Gene ID: 9966, Accession: O95150, SwissProt: O95150 |
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| Catalog # | 220334 |
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| Order / More Info | TL-1A, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 15, TNFSF15, VEGI) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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