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| Product Name | TLK1, Recombinant, Human, GST-Tag (Tousled-Like Kinase 1, KIAA0137, PKU-beta) |
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| Description | Purified (~70-90%). TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. Source: Recombinant protein corresponding to human TLK1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~135kD Specific Activity: 6.2nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_012290 |
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| Catalog # | 500501 |
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| Order / More Info | TLK1, Recombinant, Human, GST-Tag (Tousled-Like Kinase 1, KIAA0137, PKU-beta) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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