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| Product Name | RNF130-BRAF Mutant (Rex3Bex9), Active |
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| Description | 1-231 exon3 (RNF130) - 381-end or exon 9-18 (BRAF). MW: ~98 kDa. Description: Recombinant human fusion RNF130 (1-231 exon3)-BRAF (381-end or exon9-18) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: KIAA1549-BRAF is a gene fusion resulting from a tandem duplication event involving the BRAF kinase gene that have recently been identified as the most frequent genetic alteration in many cancers. The KIAA1549-BRAF fusion typically result |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay |
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| Other Names | [Homo sapiens ring finger protein 130, mRNA; E3 ubiquitin-protein ligase RNF130; E3 ubiquitin-protein ligase RNF130; ring finger protein 130; Goliath homolog; H-Goliath; RING finger protein 130; RING-type E3 ubiquitin transferase RNF130Curated] |
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| Gene, Accession, CAS # | RNF130-BRAF, Gene ID: 55819, Accession: BC108306 |
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| Catalog # | MBS515460 |
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| Order / More Info | RNF130-BRAF Mutant (Rex3Bex9), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Dougherty, M J. et al: Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol. 2010 Jul;12 (7):621-30. 2. Badiali, M. et al: KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults. Brain Pathol. 2012 Nov;22 (6):841-7. |
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