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| Product Name | FMOC-L-Leucine |
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| Description | Purity >98%. Peroxisome proliferator-activated receptor Gamma (PPARGamma) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolis. Natural agonists of PPARGamma include fatty acids (e.g., linoleic acid and 15-deoxy-Delta12,14 -prostaglandin J2 ), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists. FMOC-L-leucine is a partial agonist of PPARGamma. It activates PPARGamma with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone. FMOC-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity. As a result, it is classified as a selective PPARGamma modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine, FMOC-Leu, NPC 15199, NSC 334290 |
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| Gene, Accession, CAS # | CAS: 35661-60-0 |
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| Catalog # | LS-H7833 |
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| Order / More Info | FMOC-L-Leucine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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