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| Product Name | IL-12 p80, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80kD disulfide linked homodimer consisting of two p40 chains of IL-12. Source: Recombinant protein corresponding to human IL-12 p80, expressed in (BTI-Tn-5B1-4) Hi-5 Insect Cells. Molecular Weight: ~80kD Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTC |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-12 p80, Recombinant, Human (NKSF, CTL Maturation Factor, TCMF, Cytotoxic Lymphocyte Maturation Factor, CLMF, TSF, Edodekin-alpha, IL-12) |
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| Gene, Accession, CAS # | IL12B, Gene ID: 3593, SwissProt: P29460 |
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| Catalog # | 219891 |
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| Order / More Info | IL-12 p80, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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