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| Product Name | NR1H4, Recombinant, Human, aa1-476, His-SUMO-Tag (Bile Acid Receptor) |
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| Description | Purity ~90% (SDS-PAGE). Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. Source: Recombinant protein corresponding to aa1-476 from human NR1H4, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~70.7kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Farnesoid X-activated receptor, Farnesol receptor HRR-1 Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
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| Gene, Accession, CAS # | SwissProt: Q96RI1 |
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| Catalog # | 374465 |
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| Order / More Info | NR1H4, Recombinant, Human, aa1-476, His-SUMO-Tag (Bile Acid Receptor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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