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| Product Name | Urokinase, Human (Abbokinase, Urokinase-type Plasminogen Activator, uPA, UK) |
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| Description | Highly Purified (~95%). Urokinase (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a serine protease (EC 3.4.21.73). Urokinase is a two-chain glycoprotein containing 411aa with 12 dissulfide bonds. Its molecular weight is 54kD. Urokinase is synthesized as a zymogen form (prourokinase or single chain urokinase), and is activated by proteolytic cleavage between L158 and I159. The two resulting chains are kept together by a disulfide bond. Urokinase is a secreted protein. Expressed in the prostate gland and prostate cancers. Post-translational modification Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive zymogen form of the serine protease plasmin. Activation of plasmin trigger |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209302 |
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| Order / More Info | Urokinase, Human (Abbokinase, Urokinase-type Plasminogen Activator, uPA, UK) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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