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| Product Name | Factor Va, Bovine |
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| Description | Purity ≥95%. Factor Va is prepared by activating purified factor V with thrombin and is subsequently purified by immunoaffinity chromatography (2). This process results in cofactor preparations which are free of both activation peptides and thrombin. Purity is determined by SDS-PAGE analysis and activity is measured in a factor Va clotting assay. Participation of Factor Va in Prothrombinase: Factor Va, composed of a heavy (VaH) and light (VaL) chain, binds to negatively charged phospholipid membranes and effectively serves as a receptor for membrane bound factor Xa (Xa). The enzyme complex serves to convert the zymogen prothrombin (II) to the active serine protease thrombin (IIa), in a proteolytic event which removes the fragment 1.2 (F1.2) portion of prothrombin. Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex (1). The prothrombinase complex is respons |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F0011-70 |
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| Price | |
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| Order / More Info | Factor Va, Bovine from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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