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| Product Name | NFkB, p50, Human, Recombinant, His-Tag (Nuclear Factor NF-kappaB p50 Subunit) |
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| Description | Purity ~95% (SDS-PAGE). NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kB inhibitor (I-kB) family. In a conventional activatio |
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| Size | 2ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207299 |
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| Order / More Info | NFkB, p50, Human, Recombinant, His-Tag (Nuclear Factor NF-kappaB p50 Subunit) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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