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| Product Name | PRKAB2, Recombinant, Human, aa1-272, His-Tag (5'-AMP-activated Protein Kinase Subunit Beta-2) |
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| Description | Purity ~90% (SDS-PAGE). PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. PRKAB2 may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Source: Recombinant protein corresponding to aa1-272 from human PRKAB2 at N-terminal, fused to His-tag expressed in E.coli. Molecular Weight: ~32.8kD (296aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMGNTTS DRVSGERHGA KAARSEGAGG HAPGKEHKIM VGSTDDPSVF SLPDSKLPGD KEFVSWQQDL EDSVKPTQQA RPTVIRWSEG GKEVF |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 138719 |
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| Order / More Info | PRKAB2, Recombinant, Human, aa1-272, His-Tag (5'-AMP-activated Protein Kinase Subunit Beta-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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