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| Product Name | Ro 106-9920 |
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| Description | Purity >95%. Transcriptional activation by NF-?B is limited by I?BAlpha binding, which masks the NF-?B nuclear localization signal that initiates nuclear translocation. Cytokines trigger a signaling cascade of kinases that target I?BAlpha for degradation, enabling NF-?B to promote gene expression. Because NF-?B regulates the transcription of inflammatory mediators, blocking its signaling activity is regarded as an effective means to treat inflammatory diseases. Ro 106-9920 is a small molecule inhibitor of NF-?B-dependent expression of TNF-Alpha, interleukin-1Beta, and interleukin-6 (IC50 100 µM), the ubiquinating-conjugating enzyme E2UBCH7, nonspecific ubiquitination of cellular proteins, and 97 other molecular targets. In two different models of acute inflammation, Ro 106-9920 at 10-100 mg/kg has been shown to dose-dependently inhibit cytokine production in rat. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(phenylsulfinyl)-tetrazolo[1,5-b]pyridazine |
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| Gene, Accession, CAS # | CAS: 62645-28-7 |
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| Catalog # | LS-H9739 |
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| Order / More Info | Ro 106-9920 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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