| 产品详情 |
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| Product Name | Ro 67-4853 |
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| Description | Purity >98%. Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16). While only mildly potentiating mGluR5 signaling, this compound is without effect at mGluR2, mGluR4, or mGluR8, as well as at several other neural receptors. Ro 67-4853 can also directly activate mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC50 = 6.2 nM) and activation of adenylate cyclase (EC50 = 11.7 µM). Ro 67-4853 can also be used to enhance neuronal stimulation in response to the mGluR1/mGluR5 agonist DHPG, both in vivo and in vitro (EC50 = 95 nM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(9H-xanthen-9-ylcarbonyl)-carbamic acid, butyl ester |
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| Gene, Accession, CAS # | CAS: 302841-89-0 |
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| Catalog # | LS-H9745 |
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| Price | |
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| Order / More Info | Ro 67-4853 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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