| 产品详情 |
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| Product Name | Ro 90-7501 |
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| Description | Purity >98%. Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid Beta42 fibrils in a cell-based assay. Instead, extended polymeric sheets and fibrillary intermediates of amyloid Beta42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 µM). More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C)), a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist. Ro 90-7501 (10 µM) enhanced poly(I:C)-induced IFN-Beta expression, decreased NF-?B activation, and amplified the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2'-(4-aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine |
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| Gene, Accession, CAS # | CAS: 293762-45-5 |
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| Catalog # | LS-H9747 |
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| Order / More Info | Ro 90-7501 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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