| 产品详情 |
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| Product Name | RO8191 |
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| Description | Purity >98%. RO8191 is an agonist of interferon (IFN) Alpha receptor type 2 (IFNAR2) with antiviral activity (EC50 = 200 nM in an anti-hepatitis C virus (HCV) replicon assay). It exhibits 1:1 binding to the IFNAR2 extracellular domain, indicating RO8191 and IFNAR2 interact at the cell surface. RO8191 induces expression of IFN-stimulated genes, without induction of genes encoding inflammatory cytokines and chemokines, in HCV replicon cells, several cancer cell lines, and human primary hepatocytes. RO8191 induces expression of IFN-stimulated genes in vivo without induction of inflammatory cytokine and chemokine expression in mice. It also reduces HCV titer in HCV-infected humanized liver mice following oral administration. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8-(1,3,4-oxadiazol-2-yl)-2,4-bis (trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine, Ro 494-8191 |
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| Gene, Accession, CAS # | CAS: 691868-88-9 |
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| Catalog # | LS-H9748 |
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| Price | |
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| Order / More Info | RO8191 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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