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| Product Name | CTLA4 B7-1 Inhibitor Screening BioAssay™ Kit |
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| Description | The activation of naive T cells requires two signals, the specific T cell receptor recognition of MHC/Antigen on the surface of the antigen-presenting cell (APC), and the binding of B7-1 (CD80) ligand on the APC with the CD28 receptor on the T cell surface. Conversely, binding of CTLA4 to B7-1 on the T-cell surface results in an inhibitory signal and prevents T-cell activation. CTLA4:B7-1 interaction is an important drug target for the regulation of the host's response to cancer. The CTLA4:B7-1 Inhibitor Screening BioAssay™ Kit (Biotin) is designed for screening and profiling inhibitors of CTLA4:B7-1 signaling. This kit comes in a convenient 96-well format, with biotin-labeled B7-1, purified CTLA4, streptavidin-labeled HRP, and assay buffer for 100 binding reactions. The key to this kit is the high sensitivity of detection of biotin-labeled B7-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, CTLA4 is coated on a 96-well plate |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CTLA4 B7-1 Inhibitor Screening BioAssay™ Kit (Cytotoxic T-lymphocyte-associated Protein 4, CD152, CTLA-4 Counter-Receptor, B7.1, CD80) (Biotin) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 172327 |
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| Order / More Info | CTLA4 B7-1 Inhibitor Screening BioAssay™ Kit from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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