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| Product Name | PKCnu, Active, Recombinant, Human |
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| Description | Purity ~80% (SDS-PAGE). PKCnu, also known as PKD3, is a members of the protein kinase C (PKC) family of serine/threonine kinases that play critical roles in the regulation of cellular differentiation and proliferation in many cell types. PKCnu is composed of 890aa residues and the protein has 77.3% similarity to human PKC mu (PKCmu) and 77.4% similarity to mouse PKD (the mouse homolog of PKCmu) (1). The PKCnu mRNA is ubiquitously expressed in various tissues and the gene is located between markers WI-9798 and D2S177 on chromosome 2p21 region. PKCnu has two putative diacylglycerol binding C1 domains, suggesting that it may participate in a novel diacylglycerol-mediated signaling pathway (2). PKCnu is trans-located to the plasma membrane and activated by the diacylglycerol mimic phorbol 12-myristate 13-acetate. PKCnu is an important physiologic target of the B-cell receptor (BCR) and exhibits robust activation after BCR engagement (2). GPCR agonists induced a rapid activation of PKCnu by |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PKCnu, Active, Recombinant, Human (Protein Kinase C nu, Protein Kinase C nu Type, Protein Kinase D3) |
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| Gene, Accession, CAS # | PRKD3, Gene ID: 23683, Accession: NM_005813. |
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| Catalog # | 220173 |
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| Order / More Info | PKCnu, Active, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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