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| Product Name | SMURF2, Recombinant, Human, aa1-748, His-Tag (E3 Ubiquitin-Protein Ligase SMURF2) |
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| Description | Purity ~90% (SDS-PAGE). E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. Source: Recombinant protein corresponding to aa1-748 from human SMURF2, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~88.2kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2 |
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| Gene, Accession, CAS # | SwissProt: Q9HAU4 |
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| Catalog # | 375345 |
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| Order / More Info | SMURF2, Recombinant, Human, aa1-748, His-Tag (E3 Ubiquitin-Protein Ligase SMURF2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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