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| Product Name | Protein-L, Recombinant (Agarose) |
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| Description | Protein L (~36kD) is an immunoglobulin-binding protein isolated from the bacteria Peptostreptococcus magnus. Unlike Protein A and Protein G, which bind primarily through Fc regions (i.e., heavy chain) of immunoglobilins, Protein L binds Ig's through interactions with the light chains. Because no part of the heavy chain is involved in the binding interaction, Protein L binds a wider range of Ig classes than Protein A or G. Protein L binds to representatives of all classes of Ig's, including IgG, IgM, IgA, IgE and IgD. Single chain variable fragments (ScFv) and Fab fragments also bind to ProteinL. Despite this wide-ranging binding capability with respect to Ig classes, Protein L is not a universal immunoglobilin- binding protein. Binding of ProteinL to immunoglobulins is restricted to those containing kappa light chains (i.e., k chain of the VL domain). In humans and mice, kappa (k) light chains predominate. The remaining immunoglobulins have lambda (l) light chains. Furthermore, Protein |
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| Size | 2ml |
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| Concentration | n/a |
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| Applications | IP |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209161 |
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| Price | |
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| Order / More Info | Protein-L, Recombinant (Agarose) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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