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| Product Name | Immunodeficiency Virus Type 2 Subtype A Protein Vpx, Recombinant, Human, aa1-113, His-Tag (Vpx) |
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| Description | Purity ~90% (SDS-PAGE). Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. Source: Recombinant protein corresponding to aa1-113 from human Immunodeficiency Virus Type 2 Subtype A Protein Vpx, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~17.2kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Viral protein XX ORF protein |
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| Gene, Accession, CAS # | SwissProt: P18099 |
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| Catalog # | 373846 |
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| Order / More Info | Immunodeficiency Virus Type 2 Subtype A Protein Vpx, Recombinant, Human, aa1-113, His-Tag (Vpx) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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