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| Product Name | MyD88 Fragment, Recombinant, Human, aa176-280, His-Tag |
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| Description | Purity ~95%. The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MyD88 Fragment, Recombinant, Human, aa176-280, His-Tag (Myeloid Differentiation Marker 88, Myeloid Differentiation Primary Response Gene, Myeloid Differentiation Primary Response Protein MyD88) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149769 |
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| Order / More Info | MyD88 Fragment, Recombinant, Human, aa176-280, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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