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| Product Name | Growth Hormone 2, Recombinant, Human, aa27-217 (GH2, GHL, GHV) |
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| Description | Purity ~95% (SDSPAGE). Growth Hormone 2 (GH2), also known as Growth Hormone Variant (GH-V) and Placental Growth Hormone (PGH), is a secreted 22kD glycoprotein in the Placental Lactogen/Prolactin peptide hormone family. GH2 shares considerable structural and functional similarity with the pituitary-derived Growth Hormone (GH) (1-3). Mouse and rat orthologs of GH2 have not been identified, but human GH2 is bioactive in mice as well as rats (4, 5). Alternative splicing of human GH2 generates a 20kD isoform with a deletion of amino acids 32-46 and isoforms with substituted C-terminal regions (3, 6). GH2 is secreted by placental syncytiotrophoblasts into the maternal circulation beginning early in gestation and rising throughout pregnancy, as the level of circulating GH concommitantly decreases (1, 3, 7). GH2 is also present at lower concentrations in the fetal circulation and amniotic fluid (8-10). It is elevated in the amniotic fluid of Down syndrome pregnancies, and maternal and fetal c |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P01242 |
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| Catalog # | 145799 |
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| Order / More Info | Growth Hormone 2, Recombinant, Human, aa27-217 (GH2, GHL, GHV) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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