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| Product Name | Human alpha-1 PDX Recombinant Protein |
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| Description | Human alpha-1 PDX Recombinant Protein. Alpha1-PDX is a potent and selective inhibitor of furin (Ki = 0.6 nM). Alpha1-PDX was engineered by the construction of a variant of alpha1-antitrypsin that contains a minimal furin consensus sequence, RXXR. Cellular expression of alpha1-PDX effectively blocks the furin-dependent processing of protein precursors. In addition, extracellular application of alpha1-PDX can also block the processing of furin substrates. Alpha1-PDX has been shown to inhibit the processing of biologically significant proteins including many viral envelope glycoproteins, bacterial toxins, receptors and growth factors. |
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| Size | 2.5 mg |
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| Concentration | lyophilized |
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| Applications | Control: Assay Dependent, Inhibition Assays: Cell studies, 8.0-20 µM |
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| Other Names | Pyruvate Dehydrogenase Complex Component-X |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | RP-070 |
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| Order / More Info | Human alpha-1 PDX Recombinant Protein from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 9636142 |
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