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| Product Name | Neprilysin, Recombinant, Human, Western Blot Positive Control |
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| Description | Purified (≥95%). The amyloid b-peptide (Ab) of 39-43aa is constitutively produced in brain upon proteolysis of the b-amyloid precursor protein (APP) and exists as fragments of 40, 42 and 43aa (Ab40, Ab42, Ab43). In the young and healthy humans, the secreted Ab is rapidly catabolized before it can be deposited in the brain. However, upon aging or the onset of familial Alzheimer's disease, alterations in either synthesis or degradation/clearance of Ab may contribute to amyloid depositions in the brain. Ab carries cleavage sites for a number of in vivo and in vitro proteases like cathepsin D and M-13 metalloproteases. The M-13 family comprises several zinc-dependent metalloproteases like DINE, PHEX, KELL, ECE, XCE, neprilysin (NEP) and neprilysin-like proteases (NEPL-a, NEPL-b, NEPL-g). NEP [variously termed as neutral endopeptidase-24.11 (NEP), neprilysin, enkephalinase, EC3.4.24.11, common acute lymphoblastic leukemia antigen (CALLA), CD10] is the key in vivo enzyme degrading biopeptide |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | Neprilysin, Recombinant, Human, Western Blot Positive Control (Atriopeptidase, Common Acute Lymphocytic Leukemia Antigen, CALLA, Enkephalinase, Neutral Endopeptidase 24.11, NEP, Neutral Endopeptidase, CD10, MME, EPN) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | N2030-25 |
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| Order / More Info | Neprilysin, Recombinant, Human, Western Blot Positive Control from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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