| 产品详情 |
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| Product Name | CEP-33779 |
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| Description | Purity >95%. Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models of systemic lupus erythematosus, CEP-33779 reduces the production of inflammatory cytokines, decreases splenomegaly and lymphomegaly, and extends survival. It also diminishes inflammatory signaling and improves clinical scores in mice during collagen antibody-induced arthritis and collagen type II-induced arthritis. CEP-33779 induces regression of established colorectal tumors in mice, reducing angiogenesis and proliferation of tumor cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine |
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| Gene, Accession, CAS # | CAS: 1257704-57-6 |
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| Catalog # | LS-H7073 |
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| Order / More Info | CEP-33779 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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