| 产品详情 |
| Edit |   |
|---|
| Product Name | Tozasertib, Free Base |
|---|
| Description | Purity ~99%. Tozasertib is a potent inhibitor of all aurora kinases, including the A, B and C isotypes (Ki=0.6nM, 18nM and 4.6nM, respectively). It also inhibits ABL kinase (Ki=30nM), an imatinib-resistant ABL mutant (T315I) kinase (Ki=42nM), and Flt-3 (Ki=30nM). Tozasertib binds to an inactive aurora conformation. Solubility: Soluble in DMSO at 100mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-30uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. |
|---|
| Size | 10mg, 25mg, 50mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Tozasertib, Free Base (N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanyl]phenyl]cyclopropanecarboxamide, VX-680, MK-0457, VX6) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | T8078 |
|---|
| Price | |
|---|
| Order / More Info | Tozasertib, Free Base from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|