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| Product Name | MICAL2, Recombinant, Human, aa1-495, His-Tag (Protein-methionine Sulfoxide Oxidase MICAL2) |
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| Description | Purity ~85% (SDS-PAGE). Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. Source: Recombinant protein corresponding to aa1-495 from human MICAL2, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~58.48kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Molecule interacting with CasL protein 2, MICAL-2 |
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| Gene, Accession, CAS # | SwissProt: O94851 |
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| Catalog # | 374208 |
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| Order / More Info | MICAL2, Recombinant, Human, aa1-495, His-Tag (Protein-methionine Sulfoxide Oxidase MICAL2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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