| 产品详情 |
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| Product Name | ARHGEF18, Recombinant, Human, aa159-551, GST-Tag (Rho Guanine Nucleotide Exchange Factor 18) |
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| Description | Purity ~90% (SDS-PAGE). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Source: Recombinant protein corresponding to aa159-551 from human ARHGEF18, fused to GST-Tag at N-terminal expressed in E. coli. Molecular Weight: ~71.5kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 114kD Rho-specific guanine nucleotide exchange factor. p114-Rho-GEF, p114 RhoGEF Septin-associated RhoGEF SA-RhoGEF |
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| Gene, Accession, CAS # | SwissProt: Q6ZSZ5 |
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| Catalog # | 372328 |
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| Order / More Info | ARHGEF18, Recombinant, Human, aa159-551, GST-Tag (Rho Guanine Nucleotide Exchange Factor 18) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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