| 产品详情 |
| Edit |   |
|---|
| Product Name | Interleukin-36 alpha, active (IL36A), Recombinant, Human |
|---|
| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by u |
|---|
| Size | 2ug, 10ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | FIL1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, |
|---|
| Gene, Accession, CAS # | IL36A_HUMAN, SwissProt: Q9UHA7 |
|---|
| Catalog # | 348128 |
|---|
| Price | |
|---|
| Order / More Info | Interleukin-36 alpha, active (IL36A), Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|