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| Product Name | cdk6/Cyclin D3, Recombinant, Human, GST-Tag (Cyclin-dependent Kinase 6, PLSTIRE) |
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| Description | Purity ≥70%. Mammalian cells require a cyclin D-dependent kinase for the cell cycle start, yet many mesenchymal cells express three seemingly redundant D cyclins and similarly, seemingly redundant Cdk4 and Cdk6 as their kinase partners. It has been shown (1) that the Cdk6-cyclin D3 complex is unique among the D cyclin and kinase combinations in the ability to promote the cell cycle start. In an anchorage-minus G(1)-arrested rat fibroblast, only Cdk6-D3 retains kinase activity due mainly to its ability to evade inhibition by p27(KIP1) and p21(CIP1) with a resemblance to viral cyclin-bound Cdk6. Rodent fibroblasts engineered to overexpress both Cdk6 and cyclin D3 highly resist serum starvation- or cell-cell contact-imposed G(1)-arrest. In BALB/c 3T3 cells, D3 is constitutively expressed, but Cdk6 is markedly induced with concomitant activation upon stimulation with a growth-promoting factor. These results suggest a role for the Cdk6-D3 complex in regulating cell's proliferation ability i |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: X66365, M90814 |
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| Catalog # | C2576-60A |
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| Order / More Info | cdk6/Cyclin D3, Recombinant, Human, GST-Tag (Cyclin-dependent Kinase 6, PLSTIRE) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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