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| Product Name | CDK6/CyclinD1, Recombinant, Human, GST-Tag, His-tag |
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| Description | Purified (~70-90%). CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors. The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein. Source: Recombinant protein corresponding to human CDK6/CyclinD1, fused to GST-Tag and His-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~40kD, 61kD Specific Activity: 9.3nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDK6/CyclinD1, Recombinant, Human, GST-Tag, His-Tag (CDK6: PLSTIRE, MGC59692 Cyclin D1: BCL1, PRAD1, U21B31, D11S287E) |
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| Gene, Accession, CAS # | Accession: NM_001259 |
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| Catalog # | 499876 |
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| Order / More Info | CDK6/CyclinD1, Recombinant, Human, GST-Tag, His-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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