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| Product Name | CDK3, Cyclin E1, Active, Recombinant, Human, GST-Tag |
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| Description | Purified (~71%). Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Cyclin E1 functions as a regulator of the cell cycle, promoting the G1 to S phase transition by binding to and activating the cyclin dependent kinase CDK2. The abundance of cyclin E1 fluctuates during a normal cell cycle and is controlled at the level of gene transcription and by ubiquitin dependent proteolysis. Non-complexed cyclin E1 is degraded by the Cul3 pathway, however when cyclin E1 is b |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDK3, Cyclin E1, Active, Recombinant, Human, GST-Tag (Cyclin-dependent Kinase 3, Cell Division Protein Kinase 3, CDK3, CDKN3G1/S-specific Cyclin-E1, CCNE1, CCNE) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137259 |
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| Order / More Info | CDK3, Cyclin E1, Active, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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