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| Product Name | Ro-60/SS-A Antigen |
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| Description | Purity ≥90% by (SDS-PAGE). The SS-A/Ro particle contains a hY RNA (human cytoplasmic RNA) and associated proteins: a 60kD and a 52kD protein. The 52kD protein is not directly bound to the hY RNA but to the 60kD protein. It seems that it is sometimes associated, sometimes not. The Ro antigen is found in the cytoplasm but also in the nucleus. An RNA-binding protein, the Ro 60kD autoantigen, is a major target of the immune response in patients suffering from two systemic rheumatic diseases, systemic lupus erythematosus and Sjogren's syndrome. In lupus patients, anti-Ro antibodies are associated with photosensitive skin lesions and with neonatal lupus, a syndrome in which mothers with anti-Ro antibodies give birth to children with photosensitive skin lesions and a cardiac conduction defect, third degree heart block. In vertebrate cells, the Ro protein binds small RNAs of unknown function known as Y RNAs. Although the cellular function of Ro has long been mysterious, recent studies have imp |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Ro-60/SS-A Antigen (60kD), Recombinant, Human (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | R2997-22 |
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| Order / More Info | Ro-60/SS-A Antigen from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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