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| Product Name | Flagellin, Recombinant, Salmonella Typhimurium, aa1-495, His-Tag |
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| Description | Purity ~95% (SDS-PAGE) Endotoxin: ≤0.01EU/ug (LAL). Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4). Source: Native flagellin [FliC] from Salmonella enterica Serovar Typhimurium, strain ATCC14028, aa1-495, fused to His-tag at N-terminus, expressed in E. coli. Biological Activity: Activation of TLR5 in human epithelial cell assays based on NF-kB luciferase fusions, in vivo on expression of CCL20 or IL-6. TLR5 can be stimulated in vitro by Flagellin (rec.) at concentration range of 5-50ng/ml and in vivo at a starting concentration of 0.1-1ug/mouse. Inflammasome NLRC4 can be activated at a concentration range of 1-5ug/ml on bone-marrow macrophages in the presence of streptolysin O (SLO), a protein that allows delivery of exogenous molecules into the cytosol of living cells. E |
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| Size | 10ug, 3x40ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Flagellin, Recombinant, Salmonella Typhimurium, aa1-495, His-Tag (FliC, Phase 1-I Flagellin, flaF, hag, STM1959) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207183 |
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| Order / More Info | Flagellin, Recombinant, Salmonella Typhimurium, aa1-495, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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